Smart Spectrophotometric Methods Based on Feasible Mathematical Processing and Classical Chemometry for The Simultaneous Assay of Alcaftadine and Ketorolac in Their Recently Approved Pharmaceutical Formulation.

Alcaftadine (ALC) and Ketorolac tromethamine (KET) binary combination is a new co-formulated pharmaceutical product that used to treat allergic conjunctivitis. The present work utilizes three simple, precise, accurate, rapid spectrophotometric chemometric methods determine the recently released formulation. include first derivative of absorbance spectrum (Method A), dual-wavelength B), subtraction C). ICH guidelines have been validate developed methods. Linear regression lines were found over concentration range 1-9 1-12 ?g mL-1, 1-8 2-10 mL-1 ALC KET for A, B, C respectively. All showed correlation coefficients higher than 0.999, in addition low LOQ LOD which indicate high sensitivity proposed